Publication June 13, 2026

The Convergence of Down Syndrome and Alzheimer’s Disease — Scientific and Ethical Imperatives

Michael S. Rafii, M.D., Ph.D.

Source: The New England Journal of Medicine

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Publication April 19, 2026

Precision medicine for Alzheimer’s disease in Down syndrome

Sonal Sukreet, Elise K. Kim, Melissa Petersen, Fan Zhang, Sid E. O'Bryant, Michael S. Rafii, Robert A. Rissman

Source: Alzheimer's & Dementia

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Publication April 1, 2026

Decoding Alzheimer’s disease through down syndrome: insights from a genetically defined population

Jason K. Russell, Zinayida Schlachetzki, Michael S. Rafii

Source: Current Opinion in Neurology

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Publication March 8, 2026

A Comparative Effectiveness Study of Lorazepam or IVIg Versus no Treatment for Down Syndrome Regression Disorder

Jonathan D. Santoro, Saba Jafarpour, Panteha Hayati Rezvan, Mellad M. Khoshnood, Benjamin N. Vogel, Lina Nguyen, Lilia Kazerooni, Noemi A. Spinazzi, Nidhiben Anadani, Kristen S. Fisher, Robyn A. Filipink, Melanie A. Manning, Cathy Franklin, Eileen A. Quinn, Michael S. Rafii

Source: Neurology and Therapy

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Publication January 12, 2026

Concordance of Biological and Clinical Staging of Alzheimer Disease Pathology in Down Syndrome

Jason K. Russell, Zinayida Schlachetzki, Beau M. Ances, Michael S. Rafii for the Alzheimer’s Biomarker Consortium–Down Syndrome Study

Source: JAMA Neurology

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Publication January 11, 2026

Relationship of cholinergic basal forebrain atrophy with the time course of Alzheimer’s disease pathology and cognitive decline in adults with Down syndrome: a longitudinal cohort study

Jason K. Russell, Zinayida Schlachetzki, Alexander C. Conley, Brian D. Boyd, Paul A. Newhouse, Paul S. Aisen, Michael S. Rafii, for the Alzheimer's Biomarker Consortium on Down Syndrome Study

Source: Alzheimer's & Dementia

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Publication December 19, 2025

“Being brave, being seen, and having your voice heard”: Perspectives of self-advocates and families toward accessible and impactful research of Alzheimer’s disease in down syndrome

Sarah Walter, Lauren Ptomey, Elizabeth Head, Ann Cohen, Joseph Mike Briones, Henry Shaw, Brandon Carter, Jessica Kishner, Willie Pestolesi, Anthony Sciullo, Katy Kolb Olmstead, Aurelia Carter, Sara Kishner, Amy Kolb Tucker, Lissa Pestolesi, Maria Briones, Dana Sciullo, Kay Sciullo, Pam Shaw, Perry Chen, Michael S. Rafii

Source: Alzheimer's & Dementia

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Publication September 1, 2025

Down syndrome and Alzheimer’s disease: insights into biomarkers, clinical symptoms, and pathology

Michael S. Rafii, Zinayida Schlachetzki, Isabel Barroeta, Elizabeth Head, Juan Fortea, Beau M. Ances

Source: The Lancet

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Publication July 21, 2025

Amyloid-lowering immunotherapies for Alzheimer disease: current status and future directions

Michael S. Rafii, Paul S. Aisen

Source: Nature Reviews Neurology

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